Clinical teams in the Nottinghamshire Healthcare NHS Foundation Trust’s Early Intervention in Psychosis Services have been praised for their contribution to a highly successful national mental health research study.

The nationwide study being conducted at 35 sites is exploring the presence of antibodies in patients who have had their first experiences of psychosis.

The “Prevalence of Pathogenic Antibodies in Psychosis” or “PPiP” study, co-ordinated by the Clinical Research Network - East Midlands (based at the Institute of Mental Health), has smashed its participant recruitment target by 10%. This has enabled significant research to be carried out establishing the implications of some psychoses linking to an autoimmune disorder.

The success of our Nottingham research and clinical team has generated a lot of national excitement and could lead to profound changes in the future treatment of psychosis – moving towards a medical rather than psychiatric response.


(The Institute of Mental Health is a partnership between Nottinghamshire Healthcare NHS Foundation Trust and the University of Nottingham.)